Spinal cord injuries exhibit paralysis of limbs according to level and extent of spinal cord damaged by the injury. It affects all four limbs when injury occurs at neck affecting cervical region of spinal cord while thoracic and lumbar injury causes weakness of both lower limbs.
Sometimes, incomplete spinal cord injury patients are also presented with complete paralysis. At present nobody knows why viable neurons fail to produce improvement in these patients.
To find out scientific evidence for complete weakness, researchers studied effect of KCC2 agonist
in the mice. KCC2 is found on the surface of cell and transport electrolyte (chloride) out of the cell. Mice lumbar spinal cord was deprived of all brain derived impulses caused by B/L hemi section in spinal cord but it had intact dormant relay circuit. Treatment with KCC2 agonist in injured mice facilitated brain signal towards lumbar spinal cord causing functional recovery and ability to walk
. Further studies are needed to find out how this molecule acts in spinal cord injury