Good friend of mine asked me yesterday, Could you tell me, you know someone in this world who never had experienced pain?
I smiled and said; “Are you joking? Kidding with me?”
He also laughed for a while and said;” Ya its true!”
Doctors just treated, Miracle lady aged 66 years for orthopaedic hand surgery. They noticed lady was not requiring any analgesic postoperatively. Biggest surprise to them was that lady revealed a lifelong history of less fear or anxiety, painless injuries, such as frequent cuts and burns. She also told that injuries were observed to heal quickly.
Further research researchers found mutation in gene FAAH i.e. fatty acid amide hydrolase (FAAH) resulting in its reduce activity. This enzyme is responsible for breakdown of fatty acid amides in body.
Due to reduce blood level of FAAH, blood concentrations endorphins such as anandamide and related fatty-acid amides (palmitoylethanolamide and oleoylethanolamine) were significantly elevated.
These data is encouraging to find out new routes to develop FAAH-based analgesia by targeting of FAAH-OUT, which could significantly improve the treatment of postoperative pain and chronic pain or anxiety disorders.