Cancer is a disease caused by an uncontrolled division of abnormal cells in a part of the body. Cancer cells need a vascular supply to grow. Nutrients and oxygen to a tumor is provided by blood vessels while waste is removed by lymphatic vessels. A tumour and the surrounding cells secrete proteins that are members of the vascular endothelial growth factor (VEGF).
In recent study, High VEGF-C expression associated with dense lymphatic network in the mouse model drove strong production of the protein CCL21 (chemo attractant).Tumor cells usually don’t express CCL2 protein.Tumours such as breast cancer,melanoma,lung cancer have dense lymphatic network.
High levels of CCL21 are associated with tertiary lymphoid structures which may be responsible for bolstering anti-tumour immune responses and improve responsiveness to immunotherapy.