The innovative approach is developed by scientists from Nanyang Technological University; Singapore (NTU Singapore) reduced fat mass in mice by more than 30 per cent over four weeks.
The new type of skin patch contains hundreds of micro-needles. The size of micro needle is thinner than a human hair. These needles are loaded with the drug Beta-3 adrenergic receptor agonist or another drug called thyroid hormone T3 triiodothyronine.
Micro-needles become embed in the skin and becomes detach from the patch after pressing patch for two minutes. With the degradation of needle, drug molecules slowly diffuse to the energy-storing white fat underneath the skin layer, turning them into energy-burning brown fats.
Obesity is thought to be caused by an imbalance between energy intake and energy consumption. When we consume high calories it is converted in to white fat. Brown fat is a specialized fat characterized by increased energy expenditure and heat production. Brown fat has higher content of iron containing mitochondria which give it dark red or tan colour. The main function of mitochondria is the energy production.
In India, more than 22 per cent of adult women and 16 per cent of adult men are overweight (The global nutrition report).
Prof Leow said that , “These data should encourage Phase I Clinical studies in humans to translate these basic science findings to the bedside, with the hope that these microneedle patches may be developed into an established cost-effective modality for the prevention or treatment of obesity in the near future,”.
Image source: nutrition.org