Antidiabetic drug may improve dementia in Alzheimer disease.


Antidiabetic drug may improve dementia in Alzheimer disease.
Lokesh S
Neurosurgery
Antidiabetic drug may improve dementia in Alzheimer disease.

Antidiabetic drug may improve dementia in Alzheimer disease.

Alzheimer is the most common form of dementia. Alzheimer causes problems with memory, thinking and behaviour. Symptoms usually develop slowly and get worse over time to interfere with daily tasks. In India, more than 4 million people have some form of dementia. Worldwide, at least 44 million people are living with dementia. 

A triple receptor agonist (TA) is a drug which activates glucagon-like peptide-1(GIP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptors at the same time. Recent study had shown that it significantly reversed the memory deficit in mice.

Researcher have shown that; triple receptor agonist benefit by protection from synaptic loss, enhancing neurogenesis in dentate gyrus, reducing oxidative stress and neuroinflammation, reducing the total amount of ?-amyloid. The novel multiple receptor drugs were originally developed to treat type 2 diabetes.

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