Nanorobot designed by scientist from National Center for Nanoscience and Technology,Beijing,China is functionalized on the outside with a DNA aptamer and the blood coagulation protease thrombin within its inner surface.
What is nanorobot?
A nanorobot is a tiny machine designed to perform a specific task or tasks repeatedly and with precision at nanoscale dimensions (1 nm = 10-9 meter).
DNA aptamer is peptide molecules that bind to a specific target molecule i.e. a protein nucleolin which are specifically expressed on tumor-associated endothelial cells. Thrombin is key enzyme in the blood clotting system.
Using tumor-bearing mouse models, scientist demonstrated that intravenously injected DNA nanorobots deliver thrombin specifically to tumor-associated blood vessels and induce intravascular thrombosis. This causes tumor necrosis and inhibition of its growth. These nanorobots are proved safe and immunologically inert in mice and Bama miniature pigs. The study data published in Nature biotechnology show that DNA nanorobots represent a promising strategy for precise drug delivery in cancer therapy.
Study has shown successful demonstration of the technology, the first-of-its-kind study in mammals utilizing breast cancer, melanoma, ovarian and lung cancer mouse models.
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