Induced pluripotent cells work as vaccine against cancer by virtue of resemblance to developmentally immature progenitor cells. These cells are free from restriction on their growth to transform into mature cells to make different tissues in body. Injecting Induced pluripotent cells which are not able to replicate but resemble genetically to recipient host, can help to exposed recipient’s immune system to different cancer specific target. With this approach the immune system can be exposed to many different cancer-specific epitopes (Epitome is a part of an antigen molecule to which an antibody attaches itself.) simultaneously and can be highly valuable in clinical immunotherapy.
Immunotherapy is a type of treatment that stimulates the person’s natural defenses to fight against diseases such as cancer. There are several types of immunotherapy, including: Monoclonal antibodies, Oncolytic virus therapy, T-cell therapy and Cancer vaccines.
Joseph Wu, director of Stanford’s Cardiovascular Institute said “When we immunized an animal with genetically matching induced pluripotent cells, the immune system could be primed to reject the development of tumors in the future. Our findings indicate these cells may one day serve as a true patient-specific cancer vaccine”. Researcher showed successful results in mice for breast cancer, melanoma and lung cancer. Validity of these results in human being needs to be research further.
How this will work?
Induced pluripotent cells are produced from blood of the recipient. These are then injected into recipient to prime the immune system to prevent future cancer.
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