Scientist discovered new role of skin commensal in host defence. Newly discovered strain of Staphylococcus epidermidis produce 6-N-hydroxyaminopurine (6-HAP).6-N-hydroxyaminopurine is a molecule that inhibits DNA polymerase activity involved in cell proliferation.
Researcher showed Colonization of Staphylococcus epidermidis strain in mice reduces the incidence of tumors induced by UV rays. This occurs due to production of 6-N-hydroxyaminopurine by Staphylococcus epidermidis strains. Intravenous injection of 6-HAP in mice suppressed the growth of melanoma (type of skin cancer) without evidence of systemic toxicity.
Melanoma is the least common but the most dangerous skin cancer. It account for 1% of all Cancer cases. According to Word health organisation currently, between 2 and 3 million non-melanoma skin cancers and 132,000 melanoma skin cancers occur globally each year.